association between toxin-antitoxin systems and biofilm formation

conclusions the analysis recommended that ta genes are prevalent in clinical isolates of e. coli strains. the analysis revealed that hipba ta system is associated with biofilm formation. results the results of the analysis revealed that 107 e. coli isolates were potent for biofilm formation by cra. the findings by microtiter plates showed that 102 e. coli isolates were biofilm producers. the results indicated that 80%, 85%, 70%, 91% and 82% of the isolates possessed mazef, relbe, hipba, ccdab and mqsra ta loci, respectively. background toxin-antitoxin (ta) systems are found on the chromosomes and plasmids of many bacteria such as escherichia coli. the roles of ta systems in bacteria are enigmatic. multiple biological functions of ta systems are proposed including growth modulation, persistence, and biofilm formation. biofilms of e. coli are cause of urinary tract infections, as well as bacteraemia. objectives the current study aimed to find the association between biofilm formation and toxin-antitoxin systems in clinical isolates of e. coli. materials and methods a total of 150 e. coli isolates were evaluated for biofilm formation by congo red agar medium (cra) and microtiter plate assay and the presence of different ta systems including mazef, relbe, hipba, ccdab and mqsra.